Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice.

ABSTRACT: Acute physical or psychological stress can elicit adaptive behaviors that allow an organism maintain homeostasis. However, intense and/or prolonged stressors often have the opposite effect, resulting in maladaptive behaviors and curbing goal-directed action; in the extreme, this may contribute to the development of psychiatric conditions like generalized anxiety disorder, major depressive disorder, or post-traumatic stress disorder. While treatment of these disorders generally focuses on reducing reactivity to potentially threatening stimuli, there are in fact impairments across multiple domains including valence, arousal, and cognition. Here, we use the genetically stress-susceptible 129S1 mouse strain to explore the effects of stress across multiple domains. We find that 129S1 mice exhib

SUBMITTER: Rodriguez G 

PROVIDER: S-EPMC7739066 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature