Efficacy of different interventions for the treatment of postherpetic neuralgia: a Bayesian network meta-analysis.

ABSTRACT:

Objective

We aimed to perform a network meta-analysis that combined both direct and indirect evidence to compare the relative efficacy of interventional therapies to treat patients with postherpetic neuralgia (PHN) and to determine the treatments' superiority and validity.

Method

A conventional paired meta-analysis was performed. This was followed by a network meta-analysis using the Bayesian framework.

Results

Botulinum toxin type A and pulsed radiofrequency (PRF) were the two most effective individual interventions. For combination therapy, PRF + nerve block (NB) was the best choice, followed by subcutaneous injection or local infiltration (SC) + NB + ozone (O3). However, the combination of PRF + NB + SC showed reduced the efficacy compared with each treatment and w

SUBMITTER: Wen B 

PROVIDER: S-EPMC7739127 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature