Metabolic remodelling of glucose, fatty acid and redox pathways in the heart of type 2 diabetic mice.

ABSTRACT:

Key points

Hearts from type 2 diabetic animals display perturbations in excitation-contraction coupling, impairing myocyte contractility and delaying relaxation, along with altered substrate consumption patterns. Under high glucose and β-adrenergic stimulation conditions, palmitate can, at least in part, offset left ventricle (LV) dysfunction in hearts from diabetic mice, improving contractility and relaxation while restoring coronary perfusion pressure. Fluxome calculations of central catabolism in diabetic hearts show that, in the presence of palmitate, there is a metabolic remodelling involving tricarboxylic acid cycle, polyol and pentose phosphate pathways, leading to improved redox balance in cytoplasmic and mitochondrial compartments. Under high glucose and increased energy d

SUBMITTER: Cortassa S 

PROVIDER: S-EPMC7739175 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature