Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults.

ABSTRACT: Exposure to early-life stress (ELS) increases risk for poor mental and physical health outcomes that emerge at different stages across the lifespan. Yet, how age interacts with ELS to impact the expression of specific phenotypes remains largely unknown. An established limited-bedding paradigm was used to induce ELS in mouse pups over the early postnatal period. Initial analyses focused on the hippocampus, based on documented sensitivity to ELS in humans and various animal models, and the large body of data reporting anatomical and physiological outcomes in this structure using this ELS paradigm. An unbiased discovery proteomics approach revealed distinct adaptations in the non-nuclear hippocampal proteome in male versus female offspring at two distinct developmental stages: juvenile and ad

SUBMITTER: Eagleson KL 

PROVIDER: S-EPMC7739184 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature