Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior.

ABSTRACT: Maternal exposure to stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. The mechanisms through which the effects of maternal stress are transmitted to the fetus are unclear, however the placenta, as the interface between mother and fetus, is likely to play a key role. Using a rat model, we investigated a role for placental oxidative stress in conveying the effects of maternal social stress to the fetus and the potential for treatment using a nanoparticle-bound antioxidant to prevent adverse outcomes in the offspring. Maternal psychosocial stress increased circulating corticosterone in the mother, but not in the fetuses. Maternal stress also induced oxidative stress in the placenta, but not in the fetal brain. Blocking oxida

SUBMITTER: Scott H 

PROVIDER: S-EPMC7739187 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature