Programming effects of peripubertal stress on spatial learning.

ABSTRACT: Exposure to adversity during early life can have profound influences on brain function and behavior later in life. The peripubertal period is emerging as an important time-window of susceptibility to stress, with substantial evidence documenting long-term consequences in the emotional and social domains. However, little is known about how stress during this period impacts subsequent cognitive functioning. Here, we assessed potential long-term effects of peripubertal stress on spatial learning and memory using the water maze task. In addition, we interrogated whether individual differences in stress-induced behavioral and endocrine changes are related to the degree of adaptation of the corticosterone response to repeated stressor exposure during the peripubertal period. We found that, when

SUBMITTER: Tzanoulinou S 

PROVIDER: S-EPMC7739188 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature