Behavioral response to fluoxetine in both female and male mice is modulated by dentate gyrus granule cell activity.

ABSTRACT: Depression is a complex psychiatric disorder that is a major burden on society, with only ~33% of depressed patients attaining remission upon initial monotherapy with a selective serotonin reuptake inhibitor (SSRI). In preclinical studies using rodents, chronic stress paradigms, such as chronic corticosterone and social instability stress, are used to induce avoidance behaviors associated with negative affective states. Chronic fluoxetine (FLX; an SSRI) treatment reverses these chronic stress-induced behavioral changes in some, but not all mice, permitting stratification of mice into behavioral responders and non-responders to FLX. We previously reported that 5-HT_1A receptors, which are Gi-coupled inhibitory receptors, on mature granule cells (GCs) in the dentate gyrus (DG) are

SUBMITTER: Yohn CN 

PROVIDER: S-EPMC7739193 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature