Failure patterns and outcomes of dose escalation of stereotactic body radiotherapy for locally advanced pancreatic cancer: a multicenter cohort study.

ABSTRACT:

Objective

This study aims to compare recurrence patterns and outcomes of biologically effective dose (BED₁₀, α/β = 10) of 60-70 Gy with those of a BED₁₀ >70 Gy for locally advanced pancreatic cancer (LAPC).

Methods

Patients from three centers with a biopsy and a radiographically proven LAPC were retrospectively included and data were prospectively collected from June 2012 to June 2019. Radiotherapy was delivered by stereotactic body radiation therapy. Recurrences were categorized as in-field, marginal, and outside-the-field recurrence. Patients in two groups were required to receive abdominal enhanced contrast CT or MRI every 2-3 months and CA19-9 examinations every month during follow-up. Treatment-related toxicities were evaluated every month. Overall

SUBMITTER: Zhu X 

PROVIDER: S-EPMC7739203 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature