Long-term effects of asthma medication on asthma symptoms: an application of the targeted maximum likelihood estimation.

ABSTRACT:

Background

Long-term effectiveness of asthma control medication has been shown in clinical trials but results from observational studies with children and adolescents are lacking. Marginal structural models estimated using targeted maximum likelihood methods are a novel statistiscal approach for such studies as it allows to account for time-varying confounders and time-varying treatment. Therefore, we aimed to calculate the long-term risk of reporting asthma symptoms in relation to control medication use in a real-life setting from childhood to adulthood applying targeted maximum likelihood estimation.

Methods

In the prospective cohort study SOLAR (Study on Occupational Allergy Risks) we followed a German subsample of 121 asthmatic children (9-11 years old) of the ISAAC II c

SUBMITTER: Veit C 

PROVIDER: S-EPMC7739451 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature