Functional and genetic markers of niche partitioning among enigmatic members of the human oral microbiome.

ABSTRACT:

Introduction

Microbial residents of the human oral cavity have long been a major focus of microbiology due to their influence on host health and intriguing patterns of site specificity amidst the lack of dispersal limitation. However, the determinants of niche partitioning in this habitat are yet to be fully understood, especially among taxa that belong to recently discovered branches of microbial life.

Results

Here, we assemble metagenomes from tongue and dental plaque samples from multiple individuals and reconstruct 790 non-redundant genomes, 43 of which resolve to TM7, a member of the Candidate Phyla Radiation, forming six monophyletic clades that distinctly associate with either plaque or tongue. Both pangenomic and phylogenomic analyses group tongue-specific clades wit

SUBMITTER: Shaiber A 

PROVIDER: S-EPMC7739484 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature