Correlation Between Quantitative MRI and Muscle Histopathology in Muscle Biopsies from Healthy Controls and Patients with IBM, FSHD and OPMD.

ABSTRACT:

Background

Muscle MRI is increasingly used as a diagnostic and research tool in muscle disorders. However, the correlation between MRI abnormalities and histopathological severity is largely unknown.

Objective

To investigate correlations between muscle MRI abnormalities and histopathological severity in healthy controls and patients with muscle disease.

Methods

We performed quantitative MRI and histopathological analysis in 35 patients with inclusion body myositis, facioscapulohumeral muscular dystrophy or oculopharyngeal muscular dystrophy and 12 healthy controls. Participants contributed needle biopsies of the vastus lateralis and/or tibialis anterior, yielding 77 muscle biopsies with matched T1, T2 and TIRM MRI imaging. Muscle biopsies were evaluated with a semi-qu

SUBMITTER: Lassche S 

PROVIDER: S-EPMC7739972 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature