Reduction of Dendritic Inhibition in CA1 Pyramidal Neurons in Amyloidosis Models of Early Alzheimer's Disease.

ABSTRACT:

Background

In an early stage of Alzheimer's disease (AD), before the formation of amyloid plaques, neuronal network hyperactivity has been reported in both patients and animal models. This suggests an underlying disturbance of the balance between excitation and inhibition. Several studies have highlighted the role of somatic inhibition in early AD, while less is known about dendritic inhibition.

Objective

In this study we investigated how inhibitory synaptic currents are affected by elevated Aβ levels.

Methods

We performed whole-cell patch clamp recordings of CA1 pyramidal neurons in organotypic hippocampal slice cultures after treatment with Aβ-oligomers and in hippocampal brain slices from AppNL-F-G mice (APP-KI).

Results

We found a reduction of spontaneous i

SUBMITTER: Ruiter M 

PROVIDER: S-EPMC7739974 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature