Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO.

ABSTRACT:

Background

Efficacy and safety of different hemoglobin thresholds for transfusion of red blood cells (RBCs) in adults with an acute respiratory distress syndrome (ARDS) are unknown. We therefore assessed the effect of two transfusion thresholds on short-term outcome in patients with ARDS.

Methods

Patients who received transfusions of RBCs were identified from a cohort of 1044 ARDS patients. After propensity score matching, patients transfused at a hemoglobin concentration of 8 g/dl or less (lower-threshold) were compared to patients transfused at a hemoglobin concentration of 10 g/dl or less (higher-threshold). The primary endpoint was 28-day mortality. Secondary endpoints included ECMO-free, ventilator-free, sedation-free, and organ dysfunction-free composites.

Measureme

SUBMITTER: Hunsicker O 

PROVIDER: S-EPMC7740070 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature