Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models.

ABSTRACT:

Background

Most of our knowledge of the biological basis of major depressive disorder (MDD) is derived from studies of chronic stress models in rodents. While these models capture certain aspects of the behavioral and neuroendocrine features of MDD, the extent to which they reproduce the molecular pathology of the human syndrome remains unknown.

Methods

We systematically compared transcriptional signatures in two brain regions implicated in depression-medial prefrontal cortex and nucleus accumbens-of humans with MDD and of 3 chronic stress models in mice: chronic variable stress, adult social isolation, and chronic social defeat stress. We used differential expression analysis combined with weighted gene coexpression network analysis to create interspecies gene networks and

SUBMITTER: Scarpa JR 

PROVIDER: S-EPMC7740570 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature