DPP4 Gene Polymorphism Associates With Type 2 Diabetes Mellitus in Older Adults

ABSTRACT: Abstract Genetic variations of the dipeptidyl peptidase 4 enzyme (DPP-4) have been associated with glycemic disorders, especially among older adults. The objective of this study was to investigate the association of a single nucleotide polymorphism on the DPP4 gene with the occurrence of type 2 diabetes mellitus in a sample of older community-dwelling patients. Clinical, anthropometric and physiological characteristics as well as biochemical data related to lipidemia, glycemia and hormonal factors and variables related to the lifestyle were analyzed among 338 individuals aged 60 years and older from two general geriatric outpatient clinics in the Federal District, Brazil. Genotypes related to the polymorphism rs3788979 (A/G) of the DPP4 gene of these patients were determined by conventiona

SUBMITTER: Alves E 

PROVIDER: S-EPMC7740615 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature