Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms.

ABSTRACT:

Objective

There is growing interest in delivering kilohertz frequency (KHF) electrical signals to block conduction in peripheral nerves for treatment of various diseases. Previous studies used different KHF waveforms to achieve block, and it remains unclear how waveform affects nerve block parameters.

Approach

We quantified the effects of waveform on KHF block of the rat tibial nerve in vivo and in computational models. We compared block thresholds and onset responses across current-controlled sinusoids and charge-balanced rectangular waveforms with different asymmetries and duty cycles.

Main results

Sine waves had higher block thresholds than square waves, but used less power at block threshold. Block threshold had an inverse relationship with duty cycle of rectangul

SUBMITTER: Pena E 

PROVIDER: S-EPMC7742218 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature