Early initiation of prophylactic anticoagulation for prevention of COVID-19 mortality: a nationwide cohort study of hospitalized patients in the United States.

ABSTRACT:

Importance

Deaths among patients with coronavirus disease 2019 (COVID-19) are partially attributed to venous thromboembolism and arterial thromboses. Anticoagulants prevent thrombosis formation, possess anti-inflammatory and anti-viral properties, and may be particularly effective for treating patients with COVID-19.

Objective

To evaluate whether initiation of prophylactic anticoagulation within 24 hours of admission is associated with decreased risk of death among patients hospitalized with COVID-19.

Design

Observational cohort study.

Setting

Nationwide cohort of patients receiving care in the Department of Veterans Affairs, the largest integrated healthcare system in the United States.

Participants

All patients hospitalized with laboratory-confirmed SA

SUBMITTER: Rentsch CT 

PROVIDER: S-EPMC7743107 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature