Inference of Chromosome-Length Haplotypes Using Genomic Data of Three or a Few More Single Gametes.

ABSTRACT: Compared with genomic data of individual markers, haplotype data provide higher resolution for DNA variants, advancing our knowledge in genetics and evolution. Although many computational and experimental phasing methods have been developed for analyzing diploid genomes, it remains challenging to reconstruct chromosome-scale haplotypes at low cost, which constrains the utility of this valuable genetic resource. Gamete cells, the natural packaging of haploid complements, are ideal materials for phasing entire chromosomes because the majority of the haplotypic allele combinations has been preserved. Therefore, compared with the current diploid-based phasing methods, using haploid genomic data of single gametes may substantially reduce the complexity in inferring the donor's chromosomal haplo

SUBMITTER: Li R 

PROVIDER: S-EPMC7743722 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature