Impact of medication adherence to dual antiplatelet therapy on the long-term outcome of drug-eluting or bare-metal stents.

ABSTRACT:

Background

In percutaneous coronary intervention, drug-eluting stent (DES) showed better clinical outcome compared to bare-metal stent (BMS) but mostly with different DAPT durations.

Hypothesis

The clinical superiority of DES over BMS may depend on the medication adherence to dual antiplatelet therapy (DAPT).

Methods

We retrospectively enrolled all Koreans PCI patients in year 2011 (n = 47,291). Medication adherence to DAPT was assessed by proportion of days covered (PDC) per 6 months. Analysis adjusted with the clinical propensity for receiving DES or BMS and DAPT PDC of the first 6 month was performed. Primary outcome was the 5-year major adverse clinical event (MACE) risk consisting all-cause death, revascularization, shock, or stroke.

Results

Patients with

SUBMITTER: Choi JM 

PROVIDER: S-EPMC7743933 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature