Clot permeability and histopathology: is a clot's perviousness on CT imaging correlated with its histologic composition?

ABSTRACT:

Background

Clot perviousness in large vessel occlusion has been shown to be associated with improved recanalization outcomes with mechanical thrombectomy and intravenous thrombolysis.

Objective

To evaluate the association between clot perviousness based on thrombus attenuation increase (TAI) on CT, and histologic composition of clots in acute ischemic stroke (AIS).

Methods

A retrospective review was completed of patients with AIS secondary to large vessel occlusion, non-contrast CT (NCCT) and CT angiography (CTA) images, and histologic analysis of the retrieved clot. TAI was measured by subtracting clot attenuation on NCCT from the attenuation on CTA. Up to 3 regions of interest (ROIs) were evaluated on each clot; the average attenuation was used for analysis if multi

SUBMITTER: Benson JC 

PROVIDER: S-EPMC7744246 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature