B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients.

ABSTRACT:

Background

SARS-CoV-2 infection represents a global health problem that has affected millions of people. The fine host immune response and its association with the disease course have not yet been fully elucidated. Consequently, we analyze circulating B cell subsets and their possible relationship with COVID-19 features and severity.

Methods

Using a multiparametric flow cytometric approach, we determined B cell subsets frequencies from 52 COVID-19 patients, grouped them by hierarchical cluster analysis, and correlated their values with clinical data.

Results

The frequency of CD19⁺ B cells is increased in severe COVID-19 compared to mild cases. Specific subset frequencies such as transitional B cell subsets increase in mild/moderate cases but decrease with t

SUBMITTER: Sosa-Hernandez VA 

PROVIDER: S-EPMC7744304 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature