Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC7744327 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kim Jiyeon J Lee Hyun Min HM Cai Feng F Ko Bookyung B Yang Chendong C Lieu Elizabeth L EL Muhammad Nefertiti N Rhyne Shawn S Li Kailong K Haloul Mohamed M Gu Wen W Faubert Brandon B Kaushik Akash K AK Cai Ling L Kasiri Sahba S Marriam Ummay U Nham Kien K Girard Luc L Wang Hui H Sun Xiankai X Kim James J Minna John D JD Unsal-Kacmaz Keziban K DeBerardinis Ralph J RJ
Nature metabolism 20201130 12
In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumour suppressor STK11 (also known as LKB1) encoding the kinase LKB1 result in aggressive tumours prone to metastasis but with liabilities arising from reprogrammed metabolism. We previously demonstrated perturbed nitrogen metabolism and addiction to an unconventional pathway of pyrimidine synthesis in KRAS/LKB1 co-mutant cancer cells. To gain broader insight into metabolic reprogramming in NSCLC, we analys ...[more]