Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.

ABSTRACT:

Purpose

Cisplatin is a first-line chemotherapeutic for many cancers, but causes neurotoxicity including hearing loss, tinnitus, and peripheral sensory neuropathy. However, no study has comprehensively characterized risk factors for developing multiple (>1) severe neurotoxicities.

Experimental design

The relationship between multiple severe neurotoxicities and age, cumulative cisplatin dose, medical history, and lifestyle/behavioral factors was evaluated in 300 cisplatin-treated testicular cancer survivors using logistic regression. Case-control genome-wide association study (GWAS; cases, n = 104 and controls, n = 196) was also performed.

Results

Age at clinical examination (P = 6.4 × 10^-16) and cumulative cisplatin dose (P = 5.4

SUBMITTER: Trendowski MR 

PROVIDER: S-EPMC7744329 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature