Genes associated with cognitive performance in the Morris water maze: an RNA-seq study.

ABSTRACT: Learning and memory are among higher-order cognitive functions that are based on numerous molecular processes including changes in the expression of genes. To identify genes associated with learning and memory formation, here, we used the RNA-seq (high-throughput mRNA sequencing) technology to compare hippocampal transcriptomes between mice with high and low Morris water maze (MWM) cognitive performance. We identified 88 differentially expressed genes (DEGs) and 24 differentially alternatively spliced transcripts between the high- and low-MWM-performance mice. Although the sets of DEGs and differentially alternatively spliced transcripts did not overlap, both were found to be enriched with genes related to the same type of biological processes: trans-synaptic signaling, cognition, and glut

SUBMITTER: Reshetnikov VV 

PROVIDER: S-EPMC7744575 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature