Pharmacological Characterization of Orofacial Nociception in Female Rats Following Nitroglycerin Administration.

ABSTRACT: Rodent models of human disease can be valuable for understanding the mechanisms of a disease and for identifying novel therapies. However, it is critical that these models be vetted prior to committing resources to developing novel therapeutics. Failure to confirm the model can lead to significant losses in time and resources. One model used for migraine headache is to administer nitroglycerin to rodents. Nitroglycerin is known to produce migraine-like pain in humans and is presumed to do the same in rodents. It is not known, however, if the mechanism for nitroglycerin headaches involves the same pathological processes as migraine. In the absence of known mechanisms, it becomes imperative that the model not only translates into successful clinical trials but also successfully reverse trans

SUBMITTER: Caudle RM 

PROVIDER: S-EPMC7744726 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature