TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy.

ABSTRACT:

Introduction

Radiation therapy for the management of intrahepatic malignancies can adversely affect liver function. Liver damage has been associated with increased levels of inflammatory cytokines, including tumor necrosis factor alpha (TNFα). We hypothesized that an inflammatory state, characterized by increased soluble TNFα receptor (sTNFR1), mediates sensitivity of the liver to radiation.

Materials/methods

Plasma samples collected during 3 trials of liver radiation for liver malignancies were assayed for sTNFR1 level via enzyme-linked immunosorbent assay (ELISA). Univariate and multivariate logistic regression and longitudinal models were used to characterize associations between liver toxicity (defined as a ≥2-point increase in Child-Pugh [CP] score within 6 months of ra

SUBMITTER: Cousins MM 

PROVIDER: S-EPMC7744766 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature