FCGR1A Serves as a Novel Biomarker and Correlates With Immune Infiltration in Four Cancer Types.

ABSTRACT:

Background

FCGR1A encodes a protein that plays an important role in the immune response. The prognostic impact and immune infiltration of FCGR1A in heterogeneous cancers remain unclear.

Methods

Differential expression of FCGR1A between tumor and normal tissues and the discrepancies in overall survival (OS) among diverse cancer types were performed by Gene Expression Profiling Interactive Analysis. The correlation between FCGR1A and immune cells or gene marker sets of immune infiltrates was analyzed via Tumor Immune Estimation Resource (TIMER). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and protein-to-protein interaction (PPI) network were used to explore the function and related genes of FCGR1A. The relationships among these genes were furth

SUBMITTER: Xu JL 

PROVIDER: S-EPMC7744780 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature