Cytokine Network and Sexual Human Immunodeficiency Virus Transmission in Men Who Have Sex With Men.

ABSTRACT:

Background

Seminal human immunodeficiency virus (HIV) transmission from men to their partners remains the main driver of HIV epidemics worldwide. Semen is not merely a carrier of the virus, but also provides an immunological milieu that affects HIV transmission.

Methods

We collected blood and semen from people with HIV whose epidemiologically linked sexual partners either did or did not acquire HIV. Viral transmission was confirmed by phylogenetic linkage (HIV pol). We measured the concentration of 34 cytokines/chemokines by Luminex in the blood and semen of 21 source partners who transmitted HIV (transmitters) and 22 who did not transmit HIV (nontransmitters) to their sexual partners. Differences between cytokine profiles in transmitters versus nontransmitters were analyzed

SUBMITTER: Vanpouille C 

PROVIDER: S-EPMC7744977 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature