Population Incidence and Mortality of Sepsis in an Urban African Setting, 2013-2016.

ABSTRACT:

Background

Sepsis is an important cause of mortality globally, although population incidence estimates from low-income settings, including sub-Saharan Africa, are absent. We aimed to estimate sepsis incidence burden using routinely available data from a large urban hospital in Malawi.

Methods

We linked routine-care databases at Queen Elizabeth Central Hospital, Blantyre, Malawi, to provide admission and discharge data for 217 149 adults from 2013-2016. Using a definition of sepsis based on systemic inflammatory response syndrome criteria and Blantyre census population data, we calculated population incidence estimates of sepsis and severe sepsis and used negative binomial regression to assess for trends over time. Missing data were multiply imputed with chained equations.

SUBMITTER: Lewis JM 

PROVIDER: S-EPMC7744994 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature