Assessing the Role of Rare Genetic Variation in Patients With Heart Failure.

ABSTRACT:

Importance

Sequencing studies have identified causal genetic variants for distinct subtypes of heart failure (HF) such as hypertrophic or dilated cardiomyopathy. However, the role of rare, high-impact variants in HF, for which ischemic heart disease is the leading cause, has not been systematically investigated.

Objective

To assess the contribution of rare variants to all-cause HF with and without reduced left ventricular ejection fraction.

Design, setting, and participants

This was a retrospective analysis of clinical trials and a prospective epidemiological resource (UK Biobank). Whole-exome sequencing of patients with HF was conducted from the Candesartan in Heart Failure-Assessment of Reduction in Mortality and Morbidity (CHARM) and Controlled Rosuvastatin Multina

SUBMITTER: Povysil G 

PROVIDER: S-EPMC7745141 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature