MSIWarp: A General Approach to Mass Alignment in Mass Spectrometry Imaging.

ABSTRACT: Mass spectrometry imaging (MSI) is a technique that provides comprehensive molecular information with high spatial resolution from tissue. Today, there is a strong push toward sharing data sets through public repositories in many research fields where MSI is commonly applied; yet, there is no standardized protocol for analyzing these data sets in a reproducible manner. Shifts in the mass-to-charge ratio (m/z) of molecular peaks present a major obstacle that can make it impossible to distinguish one compound from another. Here, we present a label-free m/z alignment approach that is compatible with multiple instrument types and makes no assumptions on the sample's molecular composition. Our approach, MSIWarp (https://github.com/horvatovichlab/MSIWarp), finds an

SUBMITTER: Eriksson JO 

PROVIDER: S-EPMC7745203 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature