Impact of schizophrenia genetic liability on the association between schizophrenia and physical illness: data-linkage study.

ABSTRACT:

Background

Individuals with schizophrenia are at higher risk of physical illnesses, which are a major contributor to their 20-year reduced life expectancy. It is currently unknown what causes the increased risk of physical illness in schizophrenia.

Aims

To link genetic data from a clinically ascertained sample of individuals with schizophrenia to anonymised National Health Service (NHS) records. To assess (a) rates of physical illness in those with schizophrenia, and (b) whether physical illness in schizophrenia is associated with genetic liability.

Method

We linked genetic data from a clinically ascertained sample of individuals with schizophrenia (Cardiff Cognition in Schizophrenia participants, n = 896) to anonymised NHS records held in the Secure Anonymised Inform

SUBMITTER: Kendall KM 

PROVIDER: S-EPMC7745237 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature