A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population.

ABSTRACT:

Background

Hepatitis B is known to cause several forms of liver diseases including chronic hepatitis B (CHB), and hepatocellular carcinoma. Previous genome-wide association study of CHB risk has demonstrated that rs12614 of complement factor B (CFB) was significantly associated with CHB risk. In this study, fine-mapping study of previously reported GWAS single nucleotide polymorphism (SNP; CFB rs12614) was performed to validate genetic effect of rs12614 on CHB susceptibility and identify possible additional causal variants around rs12614 in a Korean population. This association study was conducted in order to identify genetic effects of CFB single nucleotide polymorphisms (SNPs) and to identify additional independent CHB susceptible causal markers within a Korean population.

Met

SUBMITTER: Seo JY 

PROVIDER: S-EPMC7745368 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature