Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.

ABSTRACT:

Background

Exposure to traffic-related air pollution (TRAP) during development and/or in adulthood has been associated in many human studies with both neurodevelopmental and neurodegenerative diseases, such as autism spectrum disorder (ASD) and Alzheimer's disease (AD) or Parkinson's disease (PD).

Methods

In the present study, C57BL/6 J mice were exposed to environmentally relevant levels (250+/-50 μg/m³) of diesel exhaust (DE) or filtered air (FA) during development (E0 to PND21). The expression of several transcription factors relevant for CNS development was assessed on PND3. To address possible mechanistic underpinnings of previously observed behavioral effects of DE exposure, adult neurogenesis in the hippocampus and laminar organization of neurons in the som

SUBMITTER: Cole TB 

PROVIDER: S-EPMC7745370 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature