Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study.

ABSTRACT:

Background

Perinatal exposure to air pollution and immune system dysregulation are two factors consistently associated with autism spectrum disorders (ASD) and other neurodevelopmental outcomes. However, little is known about how air pollution may influence maternal immune function during pregnancy.

Objectives

To assess the relationship between mid-gestational circulating levels of maternal cytokines/chemokines and previous month air pollution exposure across neurodevelopmental groups, and to assess whether cytokines/chemokines mediate the relationship between air pollution exposures and risk of ASD and/or intellectual disability (ID) in the Early Markers for Autism (EMA) study.

Methods

EMA is a population-based, nested case-control study which linked archived materna

SUBMITTER: Volk HE 

PROVIDER: S-EPMC7745402 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature