Preclinical Evaluation of a Novel ^99mTc-Labeled CB86 for Rheumatoid Arthritis Imaging.

ABSTRACT: Early diagnosis and therapy are crucial to control disease progression optimally and achieve a good prognosis in rheumatoid arthritis (RA). Previous study showed that a technetium-99m (^99mTc)-labeled TSPO ligand (^99mTc-CB256 [2-(8-(2-(bis(pyridin-2-yl)methyl)amino)acetamido)-2-(4-chlorophenyl)H-imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide] composed of a translocator protein (TSPO) ligand CB86 [[2-(4-chlorophenyl)-8-amino-imidazo[1,2-a]-pyridin-3-yl]-N,N-di-n-propylacetamide] and di-(2-picolyl)amine, a bifunctional chelate agent, was used to image a TSPO-rich cancer cell in vitro; however, few ^99mTc-CB256 in vivo evaluation has been reported so far probably due to the cytotoxicity of

SUBMITTER: Liu P 

PROVIDER: S-EPMC7745438 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature