Retrospective observational study of temporal trends and outcomes of hepatitis B screening in patients receiving rituximab.

ABSTRACT:

Objective

Hepatitis B reactivation (HBr) is strongly associated with rituximab therapy. Guidelines advise hepatitis B screening and use of preventive nucleoside analogue (NA) in patients at risk. In this study, we examined screening trends, post-screening interventions and outcomes in patients receiving rituximab in light of recommendations.

Design

Retrospective, observational study.

Setting

Single, tertiary care centre in the USA.

Participants

Patients receiving rituximab from January 2005 to December 2017.

Primary outcome

Trends of hepatitis B screening prior to initiation of rituximab.

Secondary outcome

Results of hepatitis B screening, use of preventive NA therapy and HBr incidence.

Results

Over 13 years, 2219 patients received rituxima

SUBMITTER: Haider M 

PROVIDER: S-EPMC7745525 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature