Brain gray matter abnormalities in osteoarthritis pain: a cross-sectional evaluation.

ABSTRACT:

Abstract

The interaction between osteoarthritis (OA) pain and brain properties remains minimally understood, although anatomical and functional neuroimaging studies suggest that OA, similar to other chronic pain conditions, may impact as well as partly be determined by brain properties. Here, we studied brain gray matter (GM) properties in OA patients scheduled to undergo total joint replacement surgery. We tested the hypothesis that brain regional GM volume is distinct between hip OA (HOA) and knee OA (KOA) patients, relative to healthy controls and moreover, that these properties are related to OA pain. Voxel-based morphometry group contrasts showed lower anterior cingulate GM volume only in HOA. When we reoriented the brains (flipped) to examine the hemisphere contralateral to O

SUBMITTER: Barroso J 

PROVIDER: S-EPMC7745790 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature