A Baseline Measurement of Quality of Life in 322 Adults With Osteogenesis Imperfecta.

ABSTRACT: Osteogenesis imperfecta (OI) is characterized by bone fragility and secondary features such as blue sclerae, dentinogenesis imperfecta, hearing loss, ligamentous laxity, and short stature. It was thought that health-related quality of life (QoL) in patients with OI mainly depends on the severity of the skeletal deformities. However, it has become clear that additional factors can affect the QoL in all patients with OI. In this study, we compare dimensions of QoL in adults with OI with a control population. The SF-36 questionnaire was distributed among 330 adult patients with different OI types. Results were compared with two control populations from the Netherlands. Age-matched comparisons were made with one of the two control populations. The results were summarized in eight domains: gene

SUBMITTER: Gooijer K 

PROVIDER: S-EPMC7745883 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature