Development and validation of a NanoString BASE47 bladder cancer gene classifier.

ABSTRACT:

Background

Recent molecular characterization of urothelial cancer (UC) has suggested potential pathways in which to direct treatment, leading to a host of targeted therapies in development for UC. In parallel, gene expression profiling has demonstrated that high-grade UC is a heterogeneous disease. Prognostic basal-like and luminal-like subtypes have been identified and an accurate transcriptome BASE47 classifier has been developed. However, these phenotypes cannot be broadly investigated due to the lack of a clinically viable diagnostic assay. We sought to develop and evaluate a diagnostic classifier of UC subtype with the goal of accurate classification from clinically available specimens.

Methods

Tumor samples from 52 patients with high-grade UC were profiled for BASE47 g

SUBMITTER: Kardos J 

PROVIDER: S-EPMC7745986 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature