DNA methylation biomarkers in peripheral blood of patients with head and neck squamous cell carcinomas. A systematic review.

ABSTRACT:

Background

Head and neck squamous cell carcinomas (HNSCC) are often diagnosed in advanced stages. In search of new diagnostic tools, focus has shifted towards the biological properties of the HNSCC, and the number of different biomarkers under investigation is rapidly growing.

Objectives

The objective was to review the current literature regarding aberrantly methylated DNA found in peripheral blood plasma or serum in patients with HNSCC and to evaluate the diagnostic accuracy of these changes.

Methods

The inclusion criteria were clinical studies involving patients with verified HNSCC that reported findings of aberrantly methylated DNA in peripheral blood serum or plasma. We systematically searched PubMed, OVID Embase and Cochrane Library. In addition to the search, we

SUBMITTER: Danstrup CS 

PROVIDER: S-EPMC7746174 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature