Relationship between high shear stress and OCT-verified thin-cap fibroatheroma in patients with coronary artery disease.

ABSTRACT: High-risk coronary plaques have been considered predictive of adverse cardiac events. Both wall shear stress (WSS) in patients with hemodynamically significant lesions and optical coherence tomography (OCT) -verified thin-cap fibroatheroma (TCFA) are associated with plaque rupture, the most common underlying mechanism of acute coronary syndrome. The aim of the study was to test the hypothesis that invasive coronary angiography-based high WSS is associated with the presence of TCFA detected by OCT in obstructive lesions. From a prospective study of patients who underwent OCT examination for angiographically obstructive lesions (Yellow II), we selected patients who had two angiographic projections to create a 3-dimensional reconstruction model to allow assessment of WSS. The patients were di

SUBMITTER: Okamoto N 

PROVIDER: S-EPMC7746187 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature