Allogeneic uterus transplantation in a rhesus model: A short-term graft viability study.

ABSTRACT:

Objective

This study examined the feasibility and safety of allogeneic uterus transplantation (UTx) from a living donor and assessed short-term graft viability in a rhesus model. This research is an important step towards further clinical application of UTx in humans.

Materials and methods

Four female rhesus monkeys with regular menstrual cycles were used in this study, the animals were either donors or recipients depending on ABO blood type compatibility. Retrieval surgery was performed to connect the uterus and uterine arteries together with the ovarian uterine vein from the living donor, and the vagina of the recipient was excised. After the back table had been prepared, bilateral uterine arteries were anastomosed end-to-side with the iliac externa arteries, and bilateral

SUBMITTER: Yu B 

PROVIDER: S-EPMC7746281 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature