Impact of variability in estimated glomerular filtration rate on major clinical outcomes: A nationwide population-based study.

ABSTRACT:

Background

The estimated glomerular filtration rate (eGFR), commonly estimated using the serum creatinine value, often fluctuates throughout the serial measurement. The clinical significance of GFR variation among the general population with normal renal function has not yet been demonstrated. Thus, we explored the impact of GFR variability on adverse clinical outcomes.

Methods

A nationwide retrospective cohort study using the Korean National Health Insurance System database was performed. National health screening examinees who underwent creatinine measurement ≥3 times between 2012 and 2016 were considered. Those with eGFR under 60 mL/min/m2 were excluded. The fluctuation of eGFR was represented with variability independent of the mean (VIM) index; which was calculated by t

SUBMITTER: Lee S 

PROVIDER: S-EPMC7746294 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature