CD138^- multiple myeloma cells express high level of CHK1 which correlated to overall survival in MM patient.

ABSTRACT: Multiple myeloma (MM) is a disease in which abnormal plasma cells proliferate and secrete monoclonal immunoglobulin in the bone marrow. The main characteristic of plasma cells is the expression of the cell surface antigen syndecan-1 (CD138). However, the expression of CD138 is limited to terminally differentiated plasma cells during B cell development. A small subpopulation (2~5%) of human MM cells that lack CD138 expression has been shown to possess enormous proliferation potential in vitro experiment and in animal models, and they also can differentiate into CD138⁺ plasma cells. Thus, this small subset of MM cells was regarded as myeloma cancer stem cell (MCSC). However, its characteristics associated with the pathogenesis of MM remain unclear. In this study, we analyze

SUBMITTER: Wu D 

PROVIDER: S-EPMC7746343 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature