Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC7746358 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Li Dameng D Song Huichen H Shuo Linghu L Wang Lei L Xie Ping P Li Weili W Liu Jiachen J Tong Yafei Y Zhang Chen-Yu CY Jiang Xiaohong X Li Jing J Zhang Yujing Y
Aging 20201110 22
In this study, we investigated the role of serum exosomal miR-222 in obesity-related insulin resistance. Bioinformatics analyses showed that miR-222 levels were significantly upregulated in the white adipose tissue of obese patients with insulin resistance (GSE25402 dataset) and in serum samples from type 2 diabetes mellitus (T2DM) patients (GSE90028 dataset). Moreover, analysis of miRNA expression in adipose tissue-specific Dicer knockout mice (GitHub dataset) and diabetic model mice (GSE81976 ...[more]