Intratumoral levels and prognostic significance of Fusobacterium nucleatum in cervical carcinoma.

ABSTRACT: Growing evidence suggests that microbes can influence the onset of cancer and its consequent development. By researching samples from patients afflicted by cervical cancer, we aimed to explore the associated dynamics and prognostic value of intratumoral levels of F. nucleatum. We used qPCR to analyze tumor tissues obtained from 112 cervical cancer patients in order to characterize the levels and influences of intratumoral levels of the F. nucleatum. Especially for recurrent tissues, there was a distinct observation of higher levels of F. nucleatum in cervical cancer. Patients with high burdens of F. nucleatum intratumoral infiltration exhibited correspondingly poor rates of both overall survival and progression-free survival. Measures of the levels of F. nucl

SUBMITTER: Huang ST 

PROVIDER: S-EPMC7746363 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature