Construction of immune-related gene pairs signature to predict the overall survival of osteosarcoma patients.

ABSTRACT: The purpose of this study is to establish the prognosis of osteosarcoma patients based on the characteristics of immune-related gene pairs. We used the lasso Cox regression model to construct and verify the signature consisting of 14 immune-related gene pairs. This signature can accurately predict the overall survival of osteosarcoma patients and is an independent prognostic factor for osteosarcoma patients. For this we constructed a signature-based nomogram. The results of the nomogram show that our signature can bring clinical net benefits. We then assessed the abundance of infiltrating immune cells in each sample, and combine the results of the gene set enrichment analysis of a single sample to explore the differences in the immune microenvironment between IRPG signature groups. The res

SUBMITTER: Li LQ 

PROVIDER: S-EPMC7746392 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature