Gestational weight gain, birthweight and early-childhood obesity: between- and within-family comparisons.

ABSTRACT:

Background

Associations of excessive gestational weight gain (GWG) with greater birthweight and childhood obesity may be confounded by shared familial environment or genetics. Sibling comparisons can minimize variation in these confounders because siblings grow up in similar environments and share the same genetic predisposition for weight gain.

Methods

We identified 96 289 women with live births in 2008-2014 at Kaiser Permanente Northern California. Fifteen percent of women (N = 14 417) had at least two births during the study period for sibling analyses. We assessed associations of GWG according to the Institute of Medicine (IOM) recommendations with birthweight and obesity at age 3 years, using conventional analyses comparing outcomes between mothers and sibling analyses

SUBMITTER: Badon SE 

PROVIDER: S-EPMC7746402 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature