Long-term use of antibiotics and risk of type 2 diabetes in women: a prospective cohort study.

ABSTRACT:

Background

Accumulating evidence suggested that long-term antibiotic use may alter the gut microbiome, which has, in turn, been linked to type 2 diabetes. We undertook this study to investigate whether antibiotic use was associated with increased risk of type 2 diabetes.

Methods

This prospective cohort study included women free of diabetes, cardiovascular disease and cancer in the Nurses' Health Study (NHS 2008-2014) and NHS II (2009-2017). We evaluated the overall duration of antibiotics use in the past 4 years and subsequent diabetes risk with Cox proportional-hazards regression adjusting for demography, family history of diabetes and lifestyle factors.

Results

Pooled analyses of NHS and NHS II (2837 cases, 703 934 person-years) revealed that a longer duration of an

SUBMITTER: Yuan J 

PROVIDER: S-EPMC7746404 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature